4-Aminobutyric acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

中枢神经系统中最常见的抑制性神经递质。

The most common inhibitory neurotransmitter in the central nervous system. (In Vitro):γ-Aminobutyric acid (30 μM) depolarizes cortical progenitor cells (E16 cells), results an inward current in ventricular zone (VZ) cells, and induces DNA synthesis inhibition, with half-maximal response concentration of 5 μM.Cortical plate (cp) neurons expresses glutamic acid decarboxylase (GAD), γ-Aminobutyric acid (1-5 μM; 18 h) stimulates the motility and arrests the migration of cp cells, while the chemotropic signal is involved G-protein activation.γ-Aminobutyric acid activates GABA A receptors, causing cell cycle arrest in S phase and limiting growth.(In Vivo):γ-Aminobutyric acid (33.95, 102.25, 306.75 mg/kg; p.o.; single dose) can enhance the sleep of mice.γ-Aminobutyric acid (1, 2, 4 mg/kg/d; p.o.; 30 d) alleviates anxiety and restored food utilization rate in rats, with impairment induced by Di(2-ethylhexyl) phthalate (DEHP) exposure.

γ-Aminobutyric acid (30 μM) depolarizes cortical progenitor cells (E16 cells), results an inward current in ventricular zone (VZ) cells, and induces DNA synthesis inhibition, with half-maximal response concentration of 5 μM.Cortical plate (cp) neurons expresses glutamic acid decarboxylase (GAD), γ-Aminobutyric acid (1-5 μM; 18 h) stimulates the motility and arrests the migration of cp cells, while the chemotropic signal is involved G-protein activation.γ-Aminobutyric acid activates GABA A receptors, causing cell cycle arrest in S phase and limiting growth. Cell Migration Assay Cell Line:Cortical plate (cp) neurons Concentration:1-5 μM Incubation Time:18 hoursResult:Promoted motility via G-protein activation and arrested attractantinduced migration via GABAA receptor-mediated depolarization.

γ-Aminobutyric acid (33.95, 102.25, 306.75 mg/kg; p.o.; single dose) can enhance the sleep of mice.γ-Aminobutyric acid (1, 2, 4mg/kg/d; p.o.; 30 d) alleviates anxiety and restored food utilization rate in rats, with impairment induced by Di(2-ethylhexyl) phthalate (DEHP) exposure. Animal Model:Pathogens free (SPF) Bagg’s albino (Balb/c) mice (18–20 g, 8 weeks old)Dosage:33.95, 102.25, 306.75 mg/kg Administration:Oral gavage; single dose; 20 mL/kg administration; measured in an hour Result:Prolonged the sleep duration, increased sleep rate, and shorten the sleep latency more effectively.Animal Model:Sprague-Dawley rat indued by DEHP (HY-B1945) (500 mg/kg)Dosage:1, 2, 4?mg/kg Administration:Oral gavage; combined administration; for 30 consecutive days Result:Reduced the levels of nitric oxide and nitric oxide synthase in rats treated with DEHP.

Aminalon | DF 468 | DF468 | DF-468 | Mielogen | Mielomade | Gamma-aminobutyric acid

Membrane Transporter/Ion Channel

GAT

GABA

Neurological Disease

——

56-12-2

103.12

C4H9NO2

>98% (HPLC)

Soluble in DMSO

O=C(O)CCCN

4-aminobutanoic acid

(-20℃)

With Ice Pack

≥ 2 years